This undated photo provided by the Oregon Health and Science University in March 2019 shows a baby monkey named Grady, at two weeks old, born from an experimental technology that aims to help young boys undergoing cancer treatment preserve their future fertility. Scientists froze testicular tissue from a monkey that had not yet reached puberty, and later thawed it to produce sperm used for Grady’s conception. (OHSU via AP)

Monkey birth a step to saving fertility of boys with cancer

The technique worked well enough that human testing should begin in the next few years

Scientists are closing in on a way to help young boys undergoing cancer treatment preserve their future fertility — and the proof is the first monkey born from the experimental technology.

More and more people are surviving childhood cancer, but nearly 1 in 3 will be left infertile from the chemotherapy or radiation that helped save their life.

When young adults are diagnosed with cancer, they can freeze sperm, eggs or embryos ahead of treatment. But children diagnosed before puberty can’t do that because they’re not yet producing mature eggs or sperm.

“Fertility issues for kids with cancer were ignored” for years, said University of Pittsburgh reproductive scientist Kyle Orwig. “Many of us dream of growing up and having our own families. We hope our research will help these young patients to do that.”

Orwig’s team reported a key advance Thursday: First, they froze a bit of testicular tissue from a monkey that hadn’t yet reached puberty. Later, they used it to produce sperm that, through a monkey version of IVF, led to the birth of a healthy female monkey named Grady.

The technique worked well enough that human testing should begin in the next few years, Orwig said.

“It’s a huge step forward” that should give hope to families, said Susan Taymans of the National Institute of Child Health and Human Development, which helped fund the research published in the journal Science. “It’s not like science fiction. It’s something that seems pretty attainable.”

University of Pittsburgh Medical Center and a handful of other hospitals already freeze immature testicular tissue from young cancer patients, in hopes of knowing how to use it once they’re grown and ready to have their own children.

Boys are born with stem cells inside little tubes in the testes, cells that start producing sperm after puberty’s testosterone jolt. Orwig’s goal: Keep sperm-producing stem cells safe from cancer treatment by freezing small pieces of testicular tissue, and using them to restore fertility later in life.

How? Enter the monkey research.

Orwig’s team froze tissue from young male monkeys, and then sterilized them. Once the monkeys approached puberty, the researchers thawed those tissue samples and gave them back to the original animal — implanting them just under the skin.

“We’re not hooking it up to the normal plumbing,” Orwig cautioned.

READ MORE: New B.C. pilot to probe how blood tests might improve cancer treatment

Boosted by hormones, the little pieces of tissue grew. Months later, the researchers removed them. Sure enough, inside was sperm they could collect and freeze.

Colleagues at the Oregon National Primate Research Center injected some of that sperm into eggs from female monkeys and implanted the resulting embryos. Last April, Grady was born, and “she plays and behaves just like every other monkey that was grown the normal way,” Orwig said.

If the technique sounds a little bizarre, it’s similar to a female option.

Girls’ eggs are in an immature state before puberty. Researchers have removed and frozen strips of ovarian tissue harbouring egg follicles from young women before cancer treatment, in hopes that when transplanted back later the immature eggs would resume development. It’s considered experimental even for young adults but some births have been reported. Now some hospitals bank ovarian tissue from girls, too.

Surgery involving the boys’ testicular tissue is less invasive, noted Orwig, who also is researching ways to reinsert sperm-producing stem cells where they belong rather than the more roundabout technique.

The new research shows “immature testicular tissue may become an option” to preserve boys’ fertility, Nina Neuhaus and Stefan Schlatt of the Center of Reproductive Medicine and Andrology in Muenster, Germany, wrote in an accompanying editorial.

Meanwhile, “it’s important for parents to know about this,” said Christine Hanlon of Holiday, Florida, who took her son Dylan to Pittsburgh to have his tissue stored when he was newly diagnosed with Ewing’s sarcoma at age 9.

Today Dylan is a healthy teen, and no one knows if he’ll ever need the stored tissue, one of more than 200 samples Orwig’s study has preserved. But Hanlon was thrilled to learn the research is moving along, just in case.

“You lose part of your childhood in cancer treatment,” Hanlon said. “If there was a chance I could help him have normalcy in his future, with the potential of having a family if that’s what he decided to do, I wanted to be able to.”

Lauran Neergaard, The Associated Press

Like us on Facebook and follow us on Twitter.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

PHOTOS: Nelson joins protests against racism, police brutality

The protest was similar to those being held throughout Canada and the United States

Game on? Nelson sports organizations wait and see

Nelson Baseball Association has already scrapped its season

RCMP: 93% of inspected boats on Kootenay Lake don’t have safety equipment

Weekend inspections found a high number of boats that don’t comply with national regulations

Temporary rail trail detour will allow upgrade to Nelson’s water source

City will be laying a water line between Stanley Street and Mountain Station parking lot

Water quality advisory issued for Nelson

Run-off has created a high level of turbidity in the city’s drinking water

VIDEO: A Vancouver Island black bear takes weekend nap in eagle tree

Videos captured by Terry Eissfeldt shows the bear arriving Saturday night and sleeping in on Sunday

Help the Nelson Star continue its mission to provide trusted local news

Black Press is now accepting donations to keep its papers operating

189 homes in Grand Forks area given evacuation orders

Homes are in the Nursery, Grand Forks Airport, Gilpin Rd., Johnson Flats and Granby Rd. areas

George Floyd asphyxiated by sustained pressure: family autopsy

Death sparked a wave of protests across the U.S. and abroad

COVID-19: B.C. commercial landlords can’t evict if they decline rent assistance

Emergency order ‘incentive’ for federal program, Carole James says

Investigators probe death of CN employee at Surrey rail yard

Transportation Safety Board is investigating an ‘occurrence that took place during switching operations’

Trans Mountain starts B.C. leg of pipeline twinning project

Mostly finished in Alberta, Burnaby terminal expanding

NDP getting COVID-19 wage subsidy ‘indirectly,’ B.C. Liberal leader says

Andrew Wilkinson says he’s heard no concerns from public

Most Read