More women may need breast cancer gene test, U.S. guidelines say

Recommendations aimed at women who’ve been treated for BRCA-related cancers and are now cancer-free

This undated fluorescence-coloured microscope image made available by the National Institutes of Health in September 2016 shows a culture of human breast cancer cells. (Ewa Krawczyk/National Cancer Institute via AP)

More women may benefit from gene testing for hereditary breast or ovarian cancer, especially if they’ve already survived cancer once, an influential health group recommended Tuesday.

At issue are genes called BRCA1 and BRCA2. When they’re mutated, the body can’t repair damaged DNA as well, greatly increasing the chances of breast, ovarian and certain other cancers. Gene testing allows affected women to consider steps to lower their risk, such as when actress Angelina Jolie underwent a preventive mastectomy several years ago.

Most cancer isn’t caused by BRCA mutations — they account for 5% to 10% of breast cancers and 15% of ovarian cancers — so the gene tests aren’t for everyone. But mutations cluster in families, and the U.S. Preventive Services Task Force has long recommended that doctors screen women who have relatives with BRCA-related cancers and refer those who might benefit from gene testing to a genetic counsellor to help them decide.

Tuesday, the task force expanded that advice, telling primary care doctors they should also assess women’s risk if:

— They previously were treated for breast or other BRCA-related cancers including ovarian, fallopian tube or peritoneal cancers, and now are considered cancer-free.

— Their ancestry is prone to BRCA mutations, such as Ashkenazi Jewish women.

Why screen breast cancer survivors? After all, they already know there’s a risk of recurrence.

READ MORE: B.C. oncologist changing the face of breast cancer treatment

Take, for example, someone who had a tumour removed in one breast in their 40s a decade ago, when genetic testing wasn’t as common. Even this many years later, a BRCA test still could reveal if they’re at risk for ovarian cancer — or at higher than usual risk for another tumour in their remaining breast tissue, explained task force member Dr. Carol Mangione of the University of California, Los Angeles. And it could alert their daughters or other relatives to a potential shared risk.

“It’s important to test those people now,” Mangione said. “We need to get the word out to primary care doctors to do this assessment and to make the referrals.”

Private insurers follow task force recommendations on what preventive care to cover, some at no out-of-pocket cost under rules from former President Barack Obama’s health care law. The recommendations were published in the Journal of the American Medical Association.

RELATED: Breast cancer survivor collects famous bands’ guitar strings for charity

Cancer groups have similar recommendations for BRCA testing, and increasingly urge that the newly diagnosed be tested, too, because the inherited risk can impact choices about surgery and other treatment.

Lauran Neergaard, The Associated Press

Like us on Facebook and follow us on Twitter

Just Posted

October is Plastic Free Month in Nelson

City will examine its own plastic use and encourage public to do the same

Fundraiser set for Fastlane to Paradise

The new local show’s fundraiser is Sept. 21 at Finley’s

Don Currie, local athletes win medal haul at 55-plus B.C. Games

Slocan’s Currie took home seven gold medals in track and field

Local runners tackle Toad Mountain

The 25 kilometre and 50 km event took runners over the top of Toad Mountain

VIDEO: Grad classes separated by 65 years find shared hopes, fears

The Nelson High School class of 1954 met with current L.V. Rogers Grade 12 students

Defense says burden of proof not met in double murder case against Victoria father

Closing statements begin in trial for man accused of killing daughters Christmas 2017

B.C. dog breeder banned again after 46 dogs seized

The SPCA seized the animals from Terry Baker, 66, in February 2018

Surrey mom allegedly paid $400,000 for son in U.S. college bribery scam

Xiaoning Sui, 48, was arrested in Spain on Monday night

Three dogs found shot dead in Prince George ditch

The three adult dogs appeared to be well cared for before being found with gunshot wounds, BC SPCA says

B.C. party bus company to be monitored after 40 intoxicated teens found onboard

Police received tip teens and young adults were drinking on party buses and limousines in Surrey

Rick Mercer calls out Conservative candidate in B.C. for fake meme

‘Not true. All fake. Please Stop,’ tweeted Rick Mercer in response

Bear killed in Kimberley after chasing girl, wreaking havoc on town

This particular brown-coloured bear has been the subject of many calls this summer; very food habituated, CO says

Police investigate after intoxicated teens clash with security at B.C. fair

18-year-old woman arrested and RCMP looking at possible assault in Victoria-area fall fair incident

Most Read